While
every effort has been made to make sure this electronic syllabus is error-free,
it is not official.
The definitive source of course information remains the original (paper)
syllabus distributed in class.
Course web site: http://www.lycoming.edu/~newman/courses/44405
Syllabus
Bio444/Chem444 – Biochemistry – Spring 2005
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Instructor: Jeffrey D. Newman Room: Heim 110 Phone: 570-321-4386 email: newman@lycoming.edu office hours: T 10:00-11:00 PM F 3:30-4:30 PM |
Instructor: Chriss McDonald Room: Heim 233 Phone: 570-321-4186 email: mcdonald@lycoming.edu office hours: I'm usually around |
Lecture meets MWF 2:00 –2:50 in Heim G-09
Lab meets Thursday 8:45 -11:35 in Heim 106
Course web site: http://www.lycoming.edu/~newman/courses/44405
Text: Nelson & Cox, Principles of Biochemistry, 4th Ed, 2005, Freeman Publishers.
Catalog Description of Course: Emphasis is given to the metabolism of carbohydrates, lipids, amino acids, proteins, and nucleic acids; integration of metabolism; and biochemical control mechanisms, including allosteric control, induction, repression, signal transduction as well as the various types of inhibitive control mechanisms.
Grades will be determined based on the following assessments:
Exams 4 x 100 pts = 400 pts
Phosphatase Lab Report 100 pts
Lipid Analysis Lab Report 100 pts
Integrated Informatics Project 100 pts
Problem Sets, Quizzes 4 x 25 pts = 100 pts
Total possible 800 pts
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B+ = 86.7 - 89.9% |
C+ = 76.7 – 79.9% |
D+ = 66.7 - 69.9% |
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A = 93.3 – 100% |
B = 83.3 – 86.6% |
C = 73.3 – 76.6% |
D = 63.3 – 66.6% |
F= below 60% |
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A- = 90.0 – 93.2% |
B- = 80.0 – 83.2% |
C- = 70.0 – 73.2% |
D- = 60.0 – 63.2% |
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Attendance policy: Attendance of all lectures and laboratories is expected. Absences will be noted by the instructor, and if excessive (more than 1 lab or 5 lectures), may result in a reduction of the course grade. Absences and participation will be used to determine borderline (within 0.5%) grades. Documentation (note from school nurse, physician, documentation of job interview, etc.) for excused absences must be provided to the instructor as soon as possible.
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Lecture Topics (chapter) |
Lab Activities |
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Week 1 |
Introduction, Background Review (1,2) |
pre-test, intro to online resources (computer lab) |
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Week 2 1/17 – 1/21 |
Protein Structure (3,4) Quiz 1 (1/21) |
Protein structure and sequence analysis with Chime/Protein Explorer. (computer lab) |
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Week 3 1/24 – 1/28 |
Protein Function (5) Exam 1 (1/28) |
Begin integrated informatics project (computer lab) |
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Week 4 1/31 – 2/4 |
Enzymes (6) |
Measurement of phosphatase activity |
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Week 5 2/7 – 2/11 |
Bioenergetics (13) Quiz 2 (2/11) |
Phosphatase kinetic analysis |
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Week 6 2/14 – 2/18 |
Lipids & Membranes (10, 11) IIP bibliography due (2/18) |
Phosphatase purification – Part 1 |
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Week 7 2/21 – 2/25 |
Signal Transduction (12) Exam 2 (2/25?) |
Phosphatase purification – Part 2 |
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Week 8 3/7 – 3/11 |
Carbohydrates & their metabolism (7, 14,15) IIP Sequence Analysis and Structure Views due (3/11) |
Purification of a 6xHis-tagged protein |
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Week 9 3/14 – 3/18 |
Respiration (16, 19) Phosphatase Lab report due (3/18) |
SDS-PAGE analysis of protein fractions |
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Week 10
3/21 – 3/25 |
Photosynthesis (19, 20) |
Enzyme Evolution (computer lab) |
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Week 11 3/28 – 4/1 |
Lipid Metabolism (17, 21) Exam 3 (4/1) |
GC/MS analysis of membrane lipids |
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Week 12 4/4 – 4/8 |
Amino Acid Metab. (18, 22) IIP Analytical Text due (4/8) |
GC/MS analysis of membrane lipids |
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Week 13+ 4/11 – 4/15 |
Nucleotide Metabolism, (22) Lipid Analysis Lab report due (4/15) |
Analysis of Purine auxotrophs |
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Week 14 4/18 – 4/22 |
Integration of Metabolism (23) |
Analysis of Purine auxotrophs |
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