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While every effort has been made to make sure this electronic syllabus is error-free, it is not official.
The definitive source of course information remains the original (paper) syllabus distributed in class.


Spring 1997 Brief Organic Lycoming College

Course description - This course is designed to introduce the student to the chemistry of organic compounds and survey various classes of biomolecules with regard to their structure and biological activity. The laboratory component of this course is designed to reinforce topics discussed in the lecture as well as examine some basic techniques of the two disciplines.

Faculty                  Responsibilities              Office  
Dr. Chriss McDonald*     lectures, lab, recitations    HBC 233 
Mrs. Henriette Evans     lab                           HBC G28 
 
*321-4186 (work), 433-4493 (home, call up to 10 PM [no kidding]), or e-mail (mcdonald@lycoming.edu)

Texts etc.
a. Fundamentals of General, Organic, and Biochemistry, Fifth Edition by John Holum#
b. Chemistry 115 Lab Manual, by McDonald#
c. Bound laboratory notebook by Freeman#
d. Lab safety glasses#
e. Calculator (add, subtract, multiply, divide, logs)
f. Lab deposit, $10 at lab check-in, cash only (refundable upon checkout)

#available at the bookstore

Course format
Lectures - MWF, 11:30 - 12:20, HBC G11, Attendance required.

Recitations - Thursday, 7:45 - 8:35 am and 1:00 - 1:50 PM, HBC G41. The primary method for evaluating chemistry students in testing situations is to have them work problems. In recitation we will practice the same sort of problems you will see in testing situations. Attendance expected. I will not take attendance but I might use some of the examples discussed in recitation as exam and quiz questions. I have found, that on the average, students who attend recitation in my courses get an average of one full letter grade higher than those who don't attend.

Assigned homework - Problems designed to enhance your understanding and prepare you for testing situations. A key will be posted in the secretarys office and outside the lab. Homework will not be collected. A large chunk of recitation will be devoted to working these problems.

Laboratory - T: 8:45 - 11:35 am, Tuesday (Evans), X: 8:45 - 11:35 PM Thursday (Evans), Y: 2:00 - 4:50 PM Thursday (McDonald), HBC 220, 239. Attendance required. Makeups for missed labs are usually not possible. Here you will experience what chemists actually do. Your labwork will be evaluated as described in the lab syllabus as well as on the lecture exams. Approximately 5% of each exam will be drawn from the labwork. A lab syllabus will be distributed at the first lab session. Make sure and show up with your $10 lab deposit (cash only) that first week.

Grading scheme
a. The final grade is based on the number of points obtained out of a possible 650 points. The points will be distributed as follows:

 
         intro/biography                   10 points (02%) 
         quizzes                           60 points (09%) 
         hour exams                       300 points (46%) 
         final exam (cumulative)          100 points (15%) 
         laboratory                       180 points (28%) 
         total                            650 points (100%) 
  

b. Assignment of letter grades is based on the following scale: 585 - 650 A, 520 - 584 B, 455 - 519 C, 390 - 454 D, < 390 F.

c. A word about learning chemistry. Studying chemistry is hard work for most people (this is certainly true for me). I would recommend that you work on the lecture material one hour per day outside of class for starters. Once you see how things are going this amount can be adjusted as needed (I suggest a significant increase in study time prior to an exam). If you are having trouble make sure and come and see me. Im easy to talk to and will do whatever I can to help you. A chem 115 tutor is also available (Missy DeForge, email address - defmeli@lycoming.edu). You will be responsible for all of the material listed on the following schedule for the indicated exams and quizzes. It is not sufficient to learn the material from the lecture alone. You are expected to read and think about the material prior to the lecture. We must necessarily cover a large amount of material so our pace must be geared towards those who are ready to learn. The hour exams will be somewhat cumulative in the sense that we need to know the earlier material to comprehend the latter. For an idea of what my exams are like in Chem 115 see Appendix C in the Lab Manual.

Policy on attendance-
Attendance at quizzes and exams is mandatory. Makeups will be administered only if I deem the reason for absence to be legitimate and I am made aware of the absence beforehand. Each documented, unexcused lecture absence will cost you one point from your total.

Chem 115 Lecture Schedule

DATE TOPIC                                 READING ASSN.  Q/E    DEMO/DISEASE 
1/6  introduction                          12.1 
1/8  bonding and hydrocarbon structure     12.2,3, 5.2,3 
1/10 alkane and cycloalkane nomenclature   12.5,6 
 
1/13 alkane physical properties            12.5,6 
1/15 functional groups, alkane reactions   12.4,7                bromine + alkene 
1/17 acid/base and how rxns occur          8.2,4, 5.8     quiz 1 
 
1/20 alkene nomenclature                   13.1-3 
1/22 alkene addition rxns                  13.4 
1/24 as above                              13.4, 9.1      quiz 2 
 
1/27 arenes and substitution rxns          13.7 
1/29 alcohol properties and nomenclature   14.1,2, 6.6, 6.8, 7.2 Elmers + Borax 
1/31 alcohol rxns                          14.3           quiz 3 
 
2/3  thiols                                14.6 
2/5  aldehyde/ketone nomenclature          15.1,2     
2/7   -    -                                              *exam 1* 
 
2/10 A/K redox behavior                    15.3,4                Tollen's
2/12 A/K and alcohols                      15.5 
2/14 carboxylic acid nomenclature, acidity 16.1,2 
 
2/17 as above + ester synthesis            16.2,3                benzoic acid + OH-(aq) 
2/19 amines, structure and basicity        17.1,2 
2/21 amides, structure/rxns                17.3           fatquiz 4 
 
2/24 dead of winter 
2/26 break 
2/28 week 
 
3/3  nylon 66, penicillin                  17.3                  nylon 
3/5  enantiomers                           18.1 
3/7   -    -                                              *exam 2* 
 
3/10 plane-polarized light and polarimetry 18.3 
3/12 diastereomers                         18.2                  thalidomide 
3/14 biochemistry overview                 19.1, 24.1 
 
3/17 monosaccharides                       19.2-4 
3/19 disaccharides                         19.5                  lactose intolerance  
3/21 polysaccharides                       19.6           fatquiz 5 
  
3/24 amino acid structure                  21.1 
3/26 pKa, pH, pI, and amino acids          21.1, 9.6,8 
3/28 Good Friday 
 
3/31 protein structure                     21.2-7               
4/2  -     -                                              *exam 3*        
4/4  more protein structure                21.2-7                sickle-cell anemia  

4/7  enzyme intro                          22.1 
4/9  how enzymes work                      22.2-4 
4/11 medical applications of enzymes       22.5                  myocardial infarction 
      
4/14 nucleic acid structure                24.1,2 
4/16 dna --> rna --> protein               24.3,4 
4/18 dna --> rna --> protein               24.3,4 
 
4/21 - 4/25     *F     I     N     A     L     S       W     E     E     K* 
 
Chem 115 Lab Schedule

week dates    experiment(s)                                    read  
              (due date)

1    1/7,9    Check in/Introduction                            Introduction - Obtaining Moles in Various Situations,
                                                               Appendices B, D

2    1/14,16  Simple and Fractional Distillation of a Mixture  Exp. 1 (Part 1,2)
 
3    1/21,23  Isolation of Limonene from Orange Peel, Part 1   Exp. 8 (Part 1) 
              (Exp. 1 writeup due) 
 
4    1/28,30  Identification of Analgesic Drugs by TLC         Exp. 2 
              Isolation of Limonene from Orange Peel, Part 2   Exp. 6 (Part 2)
              (Exp. 8 writeup due) 
 
5    2/4,6    Qualitative Organic Analysis                     Exp. 4 
              (Exp. 2 writeup due) 
 
6    2/11,13  Oxidation of Benzoin to Benzil, Part 1           Exp. 6 (Part 1), Oquantitave Treatment of a Typical Organic Reaction
              (Exp. 4 writeup due) 
 
7    2/18,20  Separation of Acidic and Neutral Sub., Part 1    Exp. 5 (Part 1)
              Oxidation of Benzoin to Benzil, Part 2           Exp. 6 (Part 2)
 
8    3/4,6    Synthesis of Dilantin, Part 4                    Exp. 7 (Part 4)
              Separation of Acidic and Neutral Sub., Part 2    Exp. 5 (Part 2) Melting points
              Oxidation to Benzoin to Benzil, Part 3
              (Exp. 6 writeup due)
 
9    3/11,13  Synthesis of Dilantin, Part 5                    Exp. 7 (Part 5)
              The Isolation of Limonene from..., Part 2        Exp. 8 (Part 2)
              (Exp. 5 writeup due) 
 
10   3/18,20  Characterization of Carbohydrates                Exp. 9 
              Synthesis of Dilantin, Part 6                    Exp. 7 (Part 6)
              (Exp. 7 writeup due) 
 
11   3/25,27  Amino Acids and Proteins                         Exp. 10 
              (Exp. 10 writeup due)    
 
12   4/1,3    Enyzmes 1                                        Exp. 11
              (Exp. 10 writeup due)
 
13   4/8,10   Enzymes 2                                        Exp. 12
              (Exp. 11 writeup due)    
 
14   4/15,17  Checkout     
              (Exp. 12 writeup due)    
  
GRADING: The lab component of your grade is 180 points out of the 650 for the course. There will be 11 grades for writeups (15 points each). Makeups for missed labs are usually not possible. A typical grade for a writeup can be broken down into three parts: content of the writeup (60%), yield of the product (20%), purity of the product (20%). Late lab writeups will cost you 5% per school day. The remaining 15 points of the lab grade will be based on an assessment done by the instructor and TA of your performance in the lab. Three areas will be evaluated: 1) preparation - have you read the lab and do you have a fair idea of what should transpire? 2) lab etiquette - do you clean up after yourself (including the common areas of the lab such as balances, melting point apparati...) and treat your labmates with respect?; 3) safety - are safety rules followed?

USEFUL SUPPLEMENTARY SOURCES: One part of your lab writeup requires you to list several physical properties for the compounds involved in that particular experiment. This information can be obtained most conveniently from one of the following: 1) The Merck Index - located in the lab, the reading room, and the library reference collection (RS.51); 2) The CRC Handbook of Chemistry and Physics - located in the lab, the reading room, and the library reference collection (QD.65); 3) The Aldrich Catalog - located in the lab and the reading room.


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    Last updated February 2, 1997.
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